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. 2016 Jan 12;107(1):95–102. doi: 10.1111/cas.12846

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© 2015 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Thiostrepton reduced the FOXM1 expression in TC616 soft tissue leiomyosarcoma cells, resulting in diminished cell viability and increased chemosensitivity for doxorubicin (DOX). (a) TC616 cells treated with 0.75 μM thiostrepton for 48 h showed decreased FOXM1 protein on Western blots. (b) TC616 cells were treated with 0.75 μM thiostrepton for 48 h. Real‐time quantitative PCR showed a reduction of FOXM1 transcript. (c) Treatment of TC616 cells with increasing quantities of thiostrepton for 72 h resulted in reduced numbers of viable cells compared to diluent controls. (d) Proliferation of TC616 cells treated with 0.75 μM thiostrepton, 5 ng/mL DOX, or their combination. The cells treated with both drugs showed significantly decreased cell viability compared to cells treated with each drug individually. *P < 0.05, Steel–Dwass multiple comparison test.