Table 2.

Quantification of EEG recordings

Treatment	Spike onset (min)	Amplitude (mV)	Burst onset (min)	Burst frequency (Hz)	Burst duration (sec)
KA (i.p.)	16.17 ± 3.66	3.14 ± 0.44	36.68 ± 6.73	1.27 ± 0.36	1.88 ± 0.34
Retigabine 5 mg/kg (pre-injection)	46.04 ± 11.85*	0.391 ± 0.25	22 ± 2.2	0.45+0.69*	0.94 ± 0.26
Retigabine 2 mg/kg (post-injection)	-	0.032 ± 0.024*	18.7 ± 4.58	0.12 ± 0.01**	0.62 ± 0.54*
Retigabine 5 mg/kg (post-injection)	-	3.51 ± 0.32	43.26 ± 5.31*	4.97 ± 1.02**	1.48 ± 1.67
KA (i.c.)	0.16 ± 0.028	4.01 ± 0.55	18.18 ± 2.89	1.49 ± 0.40	0.89 ± 0.14
RGB (0.25 μg/L)+KA	0.18 ± 0.068	0.863 ± 1.66	28.47 ± 4.08**	0.03 ± 0.21**	0.22 ± 85
RGB (1 μg/L)+KA	0.80 ± 0.36	3.64 ± 0.48	11.9 ± 1.68**	2.15 ± 0.32*	1.33 ± 0.12*

KA was administered by intraperitoneal or intrahippocampal injection to adult Sprague Dawley rats and EEG recordings were performed with in-depth hippocampal electrodes. Lower doses were anticonvulsant, whereas; higher doses were proconvulsant. The onset to spike activity was delayed with i.p. administration; attenuation of spike and wave activity was observed with either route of injection. Due to a wide range of spike amplitudes EEG amplitude was measured within a range to exclude signals below 0.1 mV or above 18 mV. Bars are means ± SEM of 90 min of tracing per animal per group.

^*p<0.05,

^**p<0.01. EEG, electroencephalogram; KA, kainic acid; RGB, retigabine