Table 1.

Clinical presentation

Gestational age	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5
	Full term	Full term	Full term	Full term	Full term
Age and reason for hospitalization*	3.5 mo: bronchiolitis	6 mo: tachypnea and poor weight gain	5 mo: transient tachypnea and desaturation	7 mo: failure to thrive; hypoxemia as incidental finding	1 mo: tachypnea and hypoxemia
Key findings at pulmonary presentation
Tachypnea	+	+	+	+	+
Crackles	+	−	−	−	+
Hypoxemia	+	+	+	+	+
Wheezing	−	−	−	−	−
Weight percentile	<Third percentile	Fourth percentile	<Third percentile	<Third percentile	22nd percentile
Age at neuroendocrine hyperplasia of infancy diagnosis	5.5 mo	7 mo	6 mo	7 mo	1.5 mo
Comorbidities	Oral aversion requiring g-tube; GERD	GERD	G-tube; recurrent febrile illnesses; GERD	Otitis media, trivial PDA; GERD	GERD
Prior respiratory hospitalization	Yes	No	Yes	No	No
Outcomes
Weight percentile
Age 12 mo	Seventh percentile	<Third percentile	<Third percentile	14th percentile	50th percentile†
Age 18 mo	Sixth percentile	13th percentile	<Third percentile	34th percentile	Not available
Age 24 mo	Not available	Fourth percentile	<Third percentile	45th percentile	Not available
Supplemental O2 use
Age 12 mo	1 LPM continuous	0.5–1 LPM continuous	2 LPM continuous	1.0–1.5 LPM continuous	0.5–0.75 LPM continuous†
Age 18 mo	1 LPM continuous	0.5–1 LPM sleep only	1.5 LPM continuous	0.5–1 LPM continuous	Not available
Age 24 mo	Not available	Room air (25 mo)	1 LPM continuous	0.5–1 LPM continuous	Not available

Definition of abbreviations: GERD = gastroesophageal reflux disease; LPM = liters per minute; PDA = patent ductus arteriosus.

^*Represents initial pulmonary contact.

^†Denotes data at 9 months of age.