Table 1.
Body weights and plasma lipids
| HDAd-0 |
HDAd-AI |
|||
|---|---|---|---|---|
| PLIN2+/+/apoE−/− | PLIN2−/−/apoE−/− | PLIN2+/+/apoE−/− | PLIN2−/−/apoE−/− | |
| BW (g) | 20.1 ± 1.47 | 20.5 ± 1.30 | 21.1 ± 0.55 | 20.9 ± 1.32 |
| Cholesterol (mg/dL) | ||||
| Total | 492.9 ± 32.00 | 470.6 ± 26.07 | 497.5 ± 21.68 | 486.0 ± 34.95 |
| Non-HDL-C | 458.8 ± 32.38 | 441.0 ± 26.56 | 408.6 ± 21.25 | 395.6 ± 32.28 |
| HDL-C | 34.1 ± 2.99 | 29.6 ± 2.16 | 88.8 ± 5.29*** | 90.4 ± 8.07*** |
| Total/HDL-C | 16.9 ± 2.10 | 17.4 ± 1.65 | 6.7 ± 0.65*** | 5.9 ± 0.55*** |
| Triglyceride (mg/dL) | 78.0 ± 3.84 | 82.9 ± 4.36 | 135.4 ± 7.23*** | 147.4 ± 11.46*** |
Body weights, total cholesterol, non-HDL-cholesterol, and HDL-C values represent post-treatment averages of values obtained at the 11- and 20-week time points. A more detailed table can be found in the online supplemental material (see Supplementary material online, Table S2).
***P< 0.001 with respect to HDAd-0-treated PLIN2+/+/apoE−/− and PLIN2−/−/apoE−/− mice, n=11–12 per group.