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. 2015 Dec 8;109(2):318–330. doi: 10.1093/cvr/cvv268

Figure 2.

Figure 2

TIMP-2 deficiency induces elastin fragmentation. (A–C) Representative images of serial sections from an atherosclerotic brachiocephalic artery with a marked elastin fragmentation (black arrowhead in A) which have been immunohistochemical stained for (A) elastin van Gieson, (B) smooth muscle cells, or (C) macrophages from a TIMP-2−/− Apoe−/− mouse. (D) Quantification of the number of TIMP-2+/+ Apoe−/− and TIMP-2−/− Apoe−/− mice without (black bars) or with (red bars) elastin breaks (*P < 0.05; n = 27/28 per group; data expressed as mean ± SEM). Scale bar in A represents 100 µm and is applicable to all panels.