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. 2015 Dec 8;109(2):318–330. doi: 10.1093/cvr/cvv268

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© The Author 2015. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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MMP-14 is expressed by Ly6C^lo monocytes but is rapidly up-regulated in all monocytes after adhesion. (A) Co-labelling and quantification of MMP-14 with (I) Ly6C, (II) CCR2, and (III) CX3CR1 in CD11b positively selected monocytes. Grey bars in graphs represent MMP-14-negative monocytes while green bars signify MMP-14 positive cells (*denotes P < 0.05 and ***denotes P < 0.001; n = 6). Scale bar represents 50 µm and is applicable to all panels. (B and C) QPCR for MMP-14 mRNA expression (B) and representative immunohistochemical labelling and quantification of MMP-14 protein expression, in non-adherent and adherent monocytes (n = 4; ***P < 0.001 and represents significant difference from non-adherent monocytes). Scale bar represents 50 µm and is applicable to both panels. (D) Quantification of non-adherent and adherent monocyte Ly6C, CCR2, and CX3CR1 expression (n = 4; *P < 0.05).