Table 1.
Group | Injection on d 1 | Injection on d 3 | Injection on d 5 | Injection on d 7 |
Physiologic saline control | 10.7 ± 1.5 | - | - | - |
Blank vector control | 11.4 ± 1.3 | - | - | |
IL-2 gene therapy | 25.0 ± 2.5b | 23.5 ± 2.0b | 18.3 ± 2.4b | 12.0 ± 1.8 |
IL-12 gene therapy | 39.0 ± 4.8b | 32.0 ± 3.9b | 23.0 ± 2.5b | 19.4 ± 2.1a |
IL-12-IL-2 fused gene therapy | 53.3 ± 3.7c | 49.3 ± 4.2c | 31.0 ± 2.1c | 24.3 ± 1.4c |
P < 0.05 and
P < 0.01 vs physiologic saline control and blank vector control;
P < 0.05 vs IL-2 group or IL-12 group.