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Isoleucine inhibits PRA synthesis in E. coli by allosteric inhibition of IlvA. The growth of mutant strains purF gnd ilvA pilvA (DM14683) and purF gnd ilvA pilvA219 (DM14684) is shown. Colonies of each strain were patched to nutrient agar containing chloramphenicol and replica printed to glucose-plus-adenine minimal medium plates containing chloramphenicol (A) and further supplemented with isoleucine (B) or isoleucine and thiamine (C).
