. 2016 Jan 12;7(1):e01862-15. doi: 10.1128/mBio.01862-15

TABLE 2 .

Proteins associated with the proteasome and ubiquitin pathways in the Pka1-regulated proteome of C. neoformans

Gene	Protein identification	Fold change^a		P value^b
Gene	Protein identification	Pka1 repression	Pka1 induction	P value^b
CNAG_00136	Ubiquitin-activating enzyme E1	0.177	−1.216	0.006
CNAG_00180	Ubiquitin carboxyl-terminal hydrolase	1.090	−2.260	0.004
CNAG_00482	26S proteasome regulatory subunit N10	0.715	−1.531	0.028
CNAG_01861	26S proteasome non-ATPase regulatory subunit 10	0.569	−1.739	0.026
CNAG_01881	Molecular chaperone GrpE	1.557	−2.879	0.005
CNAG_01899	Prefoldin alpha subunit	1.574	−2.132	0.031
CNAG_02239	26S protease regulatory subunit 4	0.714	−2.185	0.035
CNAG_02725	20S proteasome subunit beta 2	0.594	−1.365	0.045
CNAG_02827	Ubiquitin-like protein Nedd8	0.764	−0.761	0.028
CNAG_03627	Peptidyl-prolyl cis-trans isomerase	0.648	−1.725	0.049
CNAG_03721	26S proteasome regulatory subunit N12	1.433	−2.933	0.049
CNAG_04014	26S proteasome regulatory subunit N9	0.379	−1.537	0.021
CNAG_04071	Proteasome subunit alpha type	1.093	−1.295	0.029
CNAG_04906	26S protease regulatory subunit 10B	0.519	−0.929	0.033
CNAG_06106	Chaperone regulator	−0.603	0.152	0.006
CNAG_06175	26S proteasome regulatory subunit N2	0.228	−2.166	0.031
CNAG_06602	Cysteine-type peptidase	1.580	−2.278	0.001
CNAG_07717	Ubiquitin carboxyl-terminal hydrolase	0.606	−0.705	0.003
CNAG_07719	26S protease regulatory subunit 7	0.168	−1.619	0.021

^{^a}

Data represent P_GAL7::PKA1 strain/WT strain normalized log₂ average fold change values for three replicates determined under the respective glucose (repression) or galactose (induction) conditions.

^{^b}

Statistical analysis of Pka1 repression and Pka1 induction values was performed using Student’s t test (P value, <0.05).