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Coa contains Efb-like fibrinogen binding motifs. (A and B) Comparison of amino acid sequences of Efb-O with Coa-R0 (residues 474 to 505) (A) and with Coa-RI (residues 506 to 532) (B). Large letters in Efb-O indicate the residues critical or important for Fg binding. (C and D) Concentration-dependent inhibition of Efb-N protein (residues 30 to 104; 2 nM) (C) and Coa-C protein (residues 311 to 636; 2 nM) (D) binding to Fg by peptides Coa-R0, Coa-RI, and Efb-O.
