FIG 2 .

Inflammatory markers in small intestine bacterial overgrowth (SIBO)-positive and -negative subjects. (A) Calprotectin is a neutrophil-derived protein that, when elevated in the stool, indicates intestinal inflammation. The mean fecal calprotectin level in SIBO-positive subjects was 1,834.6 µg/g compared to 766.7 µg/g in SIBO-negative children (P = 0.004). (B) Reg 1β is a proproliferative, antiapoptotic protein secreted by damaged epithelial cells. When elevated in the stool, it indicates damage to the intestinal epithelium. Children with SIBO had a mean Reg 1β level of 116.8 µg/ml compared to 65.6 µg/ml in SIBO-negative children (P = 0.02).