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. Author manuscript; available in PMC: 2016 Jan 25.
Published in final edited form as: Immunity. 2015 Apr 21;42(4):731–743. doi: 10.1016/j.immuni.2015.03.012

Figure 1. Id2 is essential to mediate the colonization resistance and protection against C. rodentium infection.

Figure 1

(A–F) 7 weeks old RorccreId2fl/fl (KO, n=5) and their littermate wild type Id2fl/fl mice (WT, n=5) were orally inoculated with high dose (2 × 109 CFU) of C. rodentium. Body weight change (A) and survival rates (B) are shown. Fecal and blood C. rodentium titers at indicated day post infection (C, D) and C. rodentium titers from spleen and liver homogenate cultures at day 8 post infection (E)are shown. Dash line, limit of detection. (F) Histological analysis of representative colons from WT and KO mice at day 8 after infection. Scale bars, 100 μm.

(G–I) 7 weeks old KO (n=5) and their littermate WT (n=5) mice were orally inoculated with low dose (5 × 106 CFU) of C. rodentium. (G) Fecal C. rodentium titers at indicated day post infection are shown. Body weight change (H) and survival rates (I) are shown.

Each dot represents one individual mouse (C, D, E and G). Error bars represent SEM. *P<0.05, **P<0.01, ***P<0.001 (Student’s t-test). nd, nondetectable. Data are representative of three independent experiments (A–D, G–I) or two independent experiments (E, F). See also Figure S1.