Table 1.
Duration of H pylori infection and number of point mutations in exon 5-8 of the p53 gene
| Monkey | Duration of H pylori infection (yr) | Number of nucleotide (amino acid) substitutions in p53 | Atrophy score1 | Intensity of p53 immunostaining2 | |||
| Ex 5 | Ex 6 | Ex 7 | Ex 8 | - | |||
| A | 1.5 | 0(0) | 2 (1) | 0 (0) | 1 (1) | 2 | - |
| B | 2 | 4 (0) | 2 (2) | 5 (4) | 4 (3) | 3 | + |
| C | 3 | 4 (2) | 1 (0) | 2 (2) | 2 (2) | 4 | + |
| D | 3 | 2 (1) | 1 (0) | 1 (1) | 4 (2) | 5 | + |
| E | 3.5 | 5 (2) | 2 (1) | 5 (4) | 6 (4) | 4 | |
| F | 4.5 | 5 (1) | 3 (1) | 4 (3) | 5 (4) | 6 | - |
| G | 5 | 4 (1) | 3 (1) | 2 (1) | 8 (6) | 8 | + |
| H | 7.5 | 8 (5) | 2 (1) | 5 (4) | 8 (4) | 12 | ++ |
1
, The atrophy score was calculated as the sum of the histological evaluations of five gastric specimens according to Updated Sydney System.
2
, The intensity of p53 immunostaining was classified into four grades: -, no staining; +, mild staining; ++, moderate staining; +++, intense staining.