Table 5.

Relation between p53 and H pylori and gastric mucosal change (tentative opinion)

Condition	Human	Japanese monkey	Mongolian gerbil
H pylori and p53	++	++	+1
overexpression (histology)
H pylori and p53 point mutation	++	++	-
H pylori and atrophic gastritis	++	++	++
H pylori and intestinal metaplasia	++	-	++
H pylori and gastric cancer	+2	-	++

¹The p53 overexpression was observed only in gastric cancer;

²Not proven by interventional study; ++, strong evidence; +, weak evidence; -, no evidence