Table 1.
Demographics and clinical characteristics of the RRMS patients and the control subjects (two-sample t-test for group comparison).
| RRMS patients (n = 20), Mean (range) | Control subjects (n = 20), Mean (range) | P-values | |
|---|---|---|---|
| Gender (M/F) | 5/15 | 5/15 | 0.748 |
| Age (years) | 39.35 (20–57) | 38.10 (22–51) | 0.617 |
| Education level (years) | 11.35(6–16) | 12.35(9–16) | 0.322 |
| Disease duration (months) | 20.00 (3–37) | – | n/a |
| Normalized TWMLL (milliliter) | 21.68 (0.43–51.49) | – | n/a |
| TF | 0.88 × 10−2 (0.43–1.46 × 10−2) | 1.17 × 10−2 (0.99–1.72 × 10−2) | 0.10 × 10−4 |
| BPF | 0.83 (0.78–0.86) | 0.85 (0.81–0.89) | 0.49 × 10−3 |
| EDSS scores | 1.67 (0 – 2.5) | 0 | n/a |
| PASAT scores | 84.15 (61–103) | 98.60 (83–118) | 0.19 × 10−3 |
| MFIS-5 scores | 11.15 (6–17) | 0.25 (0.0–1.0) | 0.10 × 10−7 |
| Head motiona (mm) | 0.42 (0.12–0.91) | 0.37 (0.13–0.84) | 0.402 |
BPF, brain parenchymal fraction; EDSS, expanded disability status scale; F, female; PASAT, paced auditory serial addition test; RRMS, relapsing-remitting multiple sclerosis; M, male; mm, millimeters; n/a, not applicable; MFIS-5, modified fatigue impact scale-5 items; normalized TWMLL, total white matter lesion loads in the normalized/standard brain; TF, thalamic fraction.
aHead motion according to the criteria of Van Dijk.