Table 1.

Substrate scope for the nitroalkene bearing an internal alkynes with a phenyl substituent.^[a]

4	R1	R2	Yield [%][b]	d.r.[c]	ee [%][d]
a	Me	Ph	99	10:1	90
b	Et	Ph	83	>20:1	93
c	iPr	Ph	74	>20:1	92
d	Ph	Ph	95	6:1	91
e	Me	2-Cl-C6H4	73	10:1	82
f	Me	4-Me-C6H4	89	10:1	99
g[e]	Me	Me	59	20:3	86

[a] Reaction conditions: 1 (0.33 mmol), 2 (0.3 mmol), DHQN-SA1 (3 mol %), CHCl₃ (1.2 mL), RT, 1–2 h. [b] Yield of 4 after flash chromatography. [c] Determined by ¹H NMR spectroscopy. [d] Determined by HPLC using a chiral stationary phase. [e] The formation of small amounts of an additional diastereomer or regioisomer was detected.