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Interference of mizoribine on Pf-calpain activity. After isolation of the infected RBCs. the proteolytic activity of Pf-calpain was assessed by fluorogenic substrate, Suc-LLVY-AMC in the presence of ALLN (A) or Mizoribine (B). ALLN and Mizoribine suppressed the calpain enzyme activity in dose-dependent matter.
