Fig. 9.

Pleiotropic roles of CHES-1-like and jumu in cardiogenesis. Schematic illustrating the roles of the Fkh TFs in multiple cardiogenic processes. Both CHES-1-like and Jumu transcriptionally activate expression of htl via its cardiac enhancer in a mutually redundant manner to achieve proper specification of cardiac progenitors from the dorsal mesoderm. Both Fkh TFs also transcriptionally activate fz expression to mediate CM specification, but it has yet to be determined if the activation is direct. Subsequently, both Fkh TFs activate Polo kinase to bring about proper cell divisions of these cardiac progenitors, but it is not yet known whether this activation is direct.