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. 2016 Jan 13;6:18948. doi: 10.1038/srep18948

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(a) Schematic of the topography library. Top: combining circular, triangular and rectangular primitives into specific features that are repeated within a single TopoUnit. Bottom: differences in feature size, density and roundness between individual TopoUnits arrayed in a TopoChip. (b) Individual TopoUnits seeded for 4 h (top) or 24 h (middle, bottom) then labelled for Oct4 (green) or Sox2 (yellow), CellMask (red) and DAPI (blue). Scale bars: 50 μm.