Figure 2.

Sequence and conformational properties of the human microtubule-associated protein tau. (A) Schematic representation of the peptide used in these studies showing the phosphorylatable positions (dotted boxes) as well as locations of the fluorescence donor and acceptor. (B) Disorder propensity prediction from a variety of disorder predictors. Values >0.5 indicate disorder. (C) Polyproline II propensity prediction from Elam et al. (11). Shaded areas in (B) and (C) indicate the disordered and high PII region from which the model peptides were derived, which is a subregion of the proline-rich domain P1. To see this figure in color, go online.