Table 3. Associations of creatinine-standardized urinary PAH metabolites with cytokine expression levels (as the dependent variable).
| Variablea | BDNFa | ALCAMa | CRPa | MSPa | ||||
|---|---|---|---|---|---|---|---|---|
| β(95%CI) | pb | β(95%CI) | pb | β(95%CI) | pb | β(95%CI) | pb | |
| 1-hydroxypyrene | −0.135 (−0.256, −0.013) | 0.030 | 0.053 (0.008, 0.097) | 0.020 | 0.344 (0.218, 0.469) | <0.001 | 0.061 (−0.021, 0.143) | 0.143 |
| 1-hydroxynaphthalene | −0.065 (−0.194, 0.065) | 0.326 | 0.050 (0.003, 0.097) | 0.037 | 0.208 (0.072, 0.344) | 0.003 | 0.016 (−0.071, 0.102) | 0.723 |
| 2-hydroxynaphthalene | −0.047 (−0.183, 0.089) | 0.498 | 0.029 (−0.020, 0.078) | 0.248 | 0.228 (0.085, 0.371) | 0.002 | −0.055 (−0.145, 0.036) | 0.238 |
| 2-hydroxyfluorene | −0.076 (−0.205, 0.052) | 0.244 | 0.059 (0.013, 0.106) | 0.012 | 0.243 (0.108, 0.377) | <0.001 | −0.005 (−0.091, 0.081) | 0.908 |
| 9-hydroxyfluorene | −0.062 (−0.111, −0.013) | 0.014 | 0.010 (−0.008, 0.028) | 0.264 | −0.003 (−0.055, 0.050) | 0.920 | 0.004 (−0.030, 0.037) | 0.825 |
| 1-hydroxyphenanthrene | −0.003 (−0.092, 0.086) | 0.953 | 0.010 (−0.022, 0.043) | 0.535 | 0.149 (0.055, 0.242) | 0.002 | 0.039 (−0.021, 0.098) | 0.200 |
| 2-hydroxyphenanthrene | 0.005 (−0.098, 0.109) | 0.922 | 0.064 (0.027, 0.101) | 0.001 | 0.200 (0.092, 0.308) | <0.001 | 0.027 (−0.042, 0.097) | 0.436 |
| 3-hydroxyphenanthrene | 0.012 (−0.074, 0.099) | 0.781 | 0.035 (0.004, 0.066) | 0.027 | 0.108 (0.017, 0.199) | 0.020 | −0.022 (−0.080, 0.036) | 0.450 |
| 4-hydroxyphenanthrene | −0.062 (−0.113, −0.011) | 0.018 | 0.004 (−0.015, 0.023) | 0.676 | 0.014 (−0.041, 0.068) | 0.625 | 0.003 (−0.032, 0.037) | 0.884 |
| 9-hydroxyphenanthrene | −0.065 (−0.168, 0.037) | 0.212 | 0.035 (−0.002, 0.072) | 0.065 | 0.155 (0.047, 0.263) | 0.005 | 0.061 (−0.008, 0.130) | 0.081 |
| ΣOH-PAHs | −0.143 (−0.302, 0.016) | 0.078 | 0.067 (0.009, 0.124) | 0.023 | 0.389 (0.224, 0.555) | <0.001 | 0.048 (−0.059, 0.154) | 0.380 |
aParameters were ln-transformed prior to inclusion in the analysis.
bAdjusted for age, gender, BMI, smoking status, pack-years of smoking, alcohol use status, working years, and exercise.