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. 2016 Jan 13;146(2):155–183. doi: 10.3945/jn.114.203208

FIGURE 2.

FIGURE 2

Representative schematic for the effect of postexercise PRO/AA supplementation on the overall mTORC1 signaling and MPS response in human skeletal muscle. AA, amino acid; Akt, protein kinase B; AMPK, AMP-activated protein kinase; eEF2, eukaryotic elongation factor 2; eEF2K, eukaryotic elongation factor 2 kinase; eIF2B, eukaryotic initiation factor 2B; ERK1/2, extracellular-related kinase 1/2; Gator, GTPase-activating protein activity toward Rags; MPS, muscle protein synthesis; mTOR, mammalian target of rapamycin; mTORC1, mammalian target of rapamycin complex 1; PA, phosphatidic acid; Phosph, phosphorylation; PRAS40, proline-rich Akt substrate 40; PRO, protein; Rags, recombination activating genes; Raptor, regulatory-associated protein of mTOR; RE, resistance exercise; Rheb, Ras homolog enriched in brain; rpS6, ribosomal protein S6; S6K1/p70S6K1, p70 ribosomal protein S6 kinase 1; TSC1, tuberous sclerosis complex 1; TSC2, tuberous sclerosis complex 2; 4E-BP1, eukaryotic initiation factor 4E binding protein 1.