FIGURE 1.

Garlic-derived polysulfides promote cardioprotection through H₂S and NO signaling. This schematic illustrates the hypothesis that the garlic-derived diallyl polysulfides (i.e., DAS, DADS, and DATS) are potent H₂S donors that increase phosphorylation at the eNOS active site Ser¹¹⁷⁷, enhancing NO bioavailability and inducing cardioprotective mechanisms. DADS, diallyl disulfide; DAS, diallyl sulfide; DATS, diallyl trisulfide; eNOS, endothelial nitric oxide synthase; H₂S, hydrogen sulfide; RSNO, nitrosothiols.