Final body weights (A, C), hepatic TG concentrations (B, D), Oil Red O staining in liver sections (E), and Fgf21 mRNA expression (F) in mice fed SFPs or a liquid HC diet alone or with an LE. Final body weights (A), liver TGs (C), and Fgf21 mRNA (F) were measured in Expt. 1 (5 wk); and final body weights (B), liver TGs (D), and liver Oil Red O staining (E) were determined in Expt. 2 (1 wk). Panel E: red, lipid droplets; purple, nuclei. Original magnification ×400. Representative images from each group are shown. Values are means ± SEMs, n = 5/group. In panels A–D, 1-factor ANOVA was used to compare the treatments. Different letters indicate differences between the treatment groups, P < 0.05. Fgf21, fibroblast growth factor 21; HC, high-carbohydrate diet; LE, lipid emulsion; SFP, standard feed pellet.