Fgf21 transcript levels in adipose tissue (A, B) and muscle (C) of mice fed SFPs or a liquid HC diet alone or with an LE. Fgf21 expression was measured in adipose tissue in Expt. 1 (5 wk) (A) and Expt. 2 (1 wk) (B) and in muscle in Expt. 2 (C). Values are means ± SEMs, n = 5/group. One-factor ANOVA was used to compare the treatments. Different letters indicate differences between the treatment groups, P < 0.05. Fgf21, fibroblast growth factor 21; HC, high-carbohydrate diet; LE, lipid emulsion; SFP, standard feed pellet.