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. 2015 Nov 26;48(2):506–516. doi: 10.3892/ijo.2015.3268

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Copyright: © Nakayama et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Dual-color fluorescence in situ hybridization (FISH) was used to detect amplification of the CCNE1 gene in endometrial endometrioid carcinomas. (A) FISH analysis revealed a homogeneously stained region in the carcinoma portion with CCNE1 amplification. (B and D) A case of endometrial endometrioid carcinoma with positive immunoreactivity for CCNE1 and FBXW7 in endometrial carcinoma tissues. (C and E) A case with negative CCNE1 and FBXW7 staining in endometrial carcinoma tissues.