Figure 3.

Dietary GSPs inhibit tumor xenograft growth of A375 melanoma cells grown in athymic nude mice. (A) Body weights of the mice in each treatment group were monitored on a weekly basis. The body weights of the GSP-treated (0.2 and 0.5% w/w) and non-GSP-treated mice did not significantly differ throughout the duration of the experiment, n=5. (B) Volume or size of tumor xenografts were recorded twice per week in each treatment group. Average tumor volume (mm³) ± SD per mouse was calculated from each group and was plotted as a function of time. (C) Tumor xenograft tissues were harvested at the termination of the experiment at 40 days, and wet weight of the tumor per mouse in each group is reported as mean ± SD (g). Significant inhibition vs. control group (non-GSP-treated), ^*P<0.01 and ^¶P<0.001, n=5/group.