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. 2015 Dec 10;48(2):471–484. doi: 10.3892/ijo.2015.3287

Figure 1.

Figure 1

PIK3R1 overexpression reduces breast cancer cell proliferation, clonogenicity, migration and invasion. (A) MTS assays showed that at 48, 72 and 96 h, the PIK3R1 overexpressing lines showed significantly reduced levels of proliferation as compared to control lines. (B) Clonogenic assays performed with MDA-MB-231 and BT-474 cells plated at 200 cells/well. (C) Clonogenic assay showed that PIK3R1 overexpression resulted in a decrease in colony number as compared to control lines. (D) Growth curves for PIK3R1 group (n=6) vs. control (n=6) group in an in vivo proliferation assay. Tumors were weighed after animals were sacrificed at 36 days post-tumor cell injection. (E) Tumors extracted from PIK3R1 group and control group. (F and G) Migration assays performed with PIK3R1 overexpression and control cells. (H and I) Invasion assays in the control and PIK3R1-transfected cells. Data represent mean ± SD. *P<0.05; **P<0.01.