Table III.

Top three signaling pathways for PIK3R1 in breast cancer cells.

Pathway analysis	Pathway name	Total	P-value	Q-value	Gene
KEGG	Regulation of actin cytoskeleton	7	0.012	0.002	LIMK1, SLC9A1, GNG12, WASF2, PIK3R1, ARPC4, ACTN4
	Insulin signaling pathway	5	0.024	0.003	FLOT2, PRKCI, PPP1R3C, PIK3R1, PHKA2
	Apoptosis	4	0.025	0.003	APAF1, TRAF2, NFKB2, PIK3R1
GenMAPP	Lipid binding	9	0.001	<0.001	PRKCI, ANXA6, SCP2, STARD3, WDFY1, ANXA2, PREX1, PIK3R1, BPI
	Kinase activity	5	0.044	0.005	ADCK4, GALK1, AK3, CARKL, PIK3R1, APAF1, IRF1, TRAF2, PIK3R1
	Apoptosis	4	0.023	0.003
BioCarta	Role of PI3K subunit p85 in regulation of actin organization and cell migration	3	0.001	<0.001	ACTR2, PIK3R1, ARPC4
	EGF signaling pathway	3	0.004	0.001	STAT3, PIK3R1, MEF2D
	PDGF signaling pathway	3	0.004	0.001	STAT3, PIK3R1, MEF2D
	Signaling of hepatocyte growth factor receptor	3	0.009	0.002	STAT3, PIK3R1, MEF2D
	Mechanism of gene regulation by peroxisome proliferators via PPARα	3	0.020	0.003	PPARBP, EHHADH, PIK3R1