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. 2015 Dec 29;113(3):686–691. doi: 10.1073/pnas.1516442113

Table 1.

Statistical evidence on tau genotype dependence of adult survival and juvenile recruitment in the combined six populations

Int. (d) and genotype R S S/R χ2 surv P surv fA* Y EY χ2 recr P recr
Int. 1 (157)
+/+ 52 23 0.44 74 41.4
tau/+ 135 61 0.45 64 73.7
tau/tau 48 8 0.17 10 32.8
All 235 92 0.39 12.81 <0.01 0.471 148 42.78 <0.0001
Int. 2 (47)
+/+ 97 76 0.78 102 84.6
tau/+ 125 82 0.66 70 82.3
tau/tau 18 13 0.72 15 20.0
All 240 171 0.71 4.34 >0.1 0.327 187 6.67 0.035
Int. 3 (114)
+/+ 178 43 0.24 232 229.2
tau/+ 152 26 0.17 178 177.4
tau/tau 28 3 0.11 31 34.3
All 358 72 0.20 4.21 >0.1 0.279 441 0.36 >0.1
Int. 4 (106)
+/+ 275 16 0.058 530 453.5
tau/+ 204 9 0.044 272 325.2
tau/tau 34 2 0.059 35 58.3
All 513 27 0.053 * * 0.264 837 30.89 <0.0001
Ints. 1–3 (318)
+/+ 327 142 0.43 408 328.1
tau/+ 412 169 0.41 312 353.0
tau/tau 94 24 0.26 56 94.9
All 833 335 0.40 9.94 <0.01 776 40.16 <0.0001

Data are listed in the table for the three genotypes over four intervals (1–4; Fig. 1) of the study. Headings from left to right are defined as follows: interval (d) and genotype, duration of interval (int.) between trapping in days and genotype; R, mice released with tags at the beginning of the interval (including those already tagged before); S, tagged mice caught alive at the end of the interval; S/R, fraction surviving the interval; χ2 survival (surv) and P surv, test of independence of survival from genotype; fA*, relative mean frequency of the tau allele in the population in the interval, calculated from the means of the frequency among R and S; Y, young, untagged mice caught at the end of the interval and assumed born in the interval; EY, expected distribution of genotypes among these young mice on the basis of the fA* and assuming Hardy–Weinberg equilibrium; χ2 recruitment (recr) and P recr, test of the correspondence of the genotype in the prior (EY) and new (Y) cohort. In the bottom four rows, the data for intervals 1–3 are added and analyzed jointly. Note: In interval 4, the strongly reduced initial frequency of homozygote mice (6.6%) combined with the low winter population survival (5.3%) yielded an expected S for this genotype of only 2, too small to allow for χ2 testing. For these reasons, interval 4 was not included in the overall joint analysis (for intervals 1–3) in the lower part of the table. Genotype dependence of recruitment can however be tested over all four intervals combined and yields χ2 = 108.8 (P < 0.0001).