Table S1.

Alloxan treatment induces diabetes with different levels of blood glucose in C57BL/6 mice

Blood glucose	BG < 300 mg/dL	300 ≤ BG < 450 mg/dL	BG ≥ 450 mg/dL
Glucose level	Mild	Medium	High
Mouse no.	38	101	83
Percentage, %	17	45	38

C57BL/6 mice (n = 222) were induced to rendered diabetic by i.v. injecting one dose of Alloxan (70 mg per kg of body weight) at day 0. Blood glucose (BG) concentrations in mice were measured twice a week for 4 wk. By day 28, 17% of the mice had mild hyperglycemia (<300 mg/dL), 45% had medium hyperglycemia (300–450 mg/dL), and 38% had high hyperglycemia (≥450 mg/dL).