Table S4.
Estimated ORs of the linkages between social support and strain and biomarkers of physiological dysregulation across the life course (95% confidence interval)
| Social support | Social strain | |||||||
| Adolescence | Young to midadulthood | Late adulthood | Young to midadulthood | Late adulthood | ||||
| Biomarker outcomesa | Model | Add Health; age, 12–18 | MIDUS; age, 25–64 | HRS; age, 50–98 | NSHAPb; age, 57–91 | MIDUS; age, 25–64 | HRS; age, 50–98 | NSHAPb; age, 57–91 |
| Inflammation | Basicc | 1.04 | 1.00 | 0.98 | 1.01 | 1.06† | 1.05 | 1.01 |
| (0.90, 1.21) | (0.95, 1.05) | (0.94, 1.03) | (0.92, 1.11) | (1.00, 1.12) | (0.98, 1.13) | (0.93, 1.10) | ||
| Fulld | 1.09 | 1.04 | 1.01 | 0.98 | 1.01 | 1.01 | 0.96 | |
| (0.94, 1.26) | (0.99, 1.10) | (0.96, 1.06) | (0.88, 1.09) | (0.95, 1.08) | (0.94, 1.09) | (0.87, 1.06) | ||
| N | 6,747 | 599 | 801 | 860 | 599 | 801 | 860 | |
| Hypertension | Basic | 0.92 | 0.98 | 0.97 | 0.95 | 1.05 | 0.99 | 0.95 |
| (0.77, 1.11) | (0.93, 1.04) | (0.92, 1.03) | (0.86, 1.05) | (0.99, 1.12) | (0.91, 1.07) | (0.84, 1.08) | ||
| Full | 0.92 | 1.03 | 0.99 | 0.95 | 1.01 | 0.95 | 0.96 | |
| (0.76, 1.11) | (0.97, 1.10) | (0.94, 1.05) | (0.84, 1.06) | (0.94, 1.08) | (0.87, 1.04) | (0.83, 1.11) | ||
| N | 7,561 | 599 | 802 | 1,516 | 599 | 802 | 1,474 | |
| Abdominal obesity | Basic | 1.04 | 0.94* | 0.93* | 0.97 | 1.08* | 1.09* | 1.09 |
| (0.90, 1.22) | (0.89, 0.99) | (0.88, 0.98) | (0.88, 1.06) | (1.01, 1.14) | (1.00, 1.18) | (0.98, 1.22) | ||
| Full | 1.09 | 1.03 | 0.96 | 1.01 | 0.94 | 1.04 | 1.01 | |
| (0.87, 1.36) | (0.95, 1.11) | (0.91, 1.02) | (0.91, 1.11) | (0.84, 1.04) | (0.95, 1.14) | (0.89, 1.15) | ||
| N | 7,889 | 599 | 801 | 1,560 | 599 | 801 | 1,516 | |
| Overall | Basic | 1.03 | 0.95† | 0.96 | 0.93 | 1.12*** | 1.12** | 1.17** |
| Obesity | (0.87, 1.21) | (0.90, 1.00) | (0.91, 1.01) | (0.83, 1.04) | (1.05, 1.19) | (1.03, 1.21) | (1.06, 1.29) | |
| Full | 1.00 | 0.97 | 0.99 | 0.94 | 1.11** | 1.09* | 1.17** | |
| (0.85, 1.18) | (0.91, 1.03) | (0.93, 1.04) | (0.85, 1.05) | (1.03, 1.19) | (1.00, 1.19) | (1.05, 1.30) | ||
| N | 7,889 | 599 | 812 | 1,571 | 599 | 812 | 1,527 | |
***P < 0.001, **P < 0.01, *P < 0.05, †P < 0.1 (two-tailed test).
a
Measures and cut points used for each marker in Table S1.
b
Results for inflammation are based on data at wave 1 only; results for the other three markers are based on data at waves 1 and 2 and longitudinal residual change models.
c
Adjusted for age, sex, and race.
d
Adjusted for the full set of covariates in Table S3 for each dataset.