Table 1.

Estimated ORs of the linkages between social integration and biomarkers of physiological dysregulation across the life course (95% confidence intervals)

		Adolescence	Young adulthood	Young to midadulthood	Late adulthood
Biomarker outcomesa	Model	Add Health; age 12–18	Add Health; age 24–32	MIDUS; age 25–64	HRS; age 50–98	NSHAPb; age 57–91
Inflammation	Basicc	0.74*	0.76*	1.03	0.86**	0.59*
		(0.57, 0.97)	(0.61, 0.96)	(0.53, 1.98)	(0.78, 0.94)	(0.37, 0.95)
	Fulld	0.99	0.79†	1.07	0.89*	0.77
		(0.76, 1.29)	(0.62, 1.00)	(0.55, 2.10)	(0.81, 0.98)	(0.48, 1.23)
	N	6,747	6,747	863	4,323	1,153
Hypertension	Basicc	0.90	1.12	1.74	0.87*	0.46**
		(0.65, 1.24)	(0.80, 1.57)	(0.81, 3.76)	(0.78, 0.89)	(0.25, 0.85)
	Fulld	1.09	1.16	1.69	0.89*	0.41**
		(0.78, 1.52)	(0.83, 1.63)	(0.73, 3.93)	(0.80, 0.99)	(0.22, 0.76)
	N	7,561	7,561	863	4,323	1,433
Abdominal	Basicc	0.52***	0.81**	1.28	0.96	0.71
Obesity		(0.39, 0.68)	(0.63, 1.03)	(0.62, 2.65)	(0.86, 1.07)	(0.29, 1.79)
	Fulld	0.75	0.68†	0.81	1.01	0.91
		(0.49, 1.13)	(0.44, 1.04)	(0.26, 2.53)	(0.90, 1.14)	(0.38, 2.20)
	N	7,889	7,889	863	4,323	1,423
Overall	Basicc	0.59***	0.97	1.50	1.03	0.34*
Obesity		(0.44, 0.78)	(0.75, 1.26)	(0.72, 3.12)	(0.93, 1.14)	(0.13, 0.86)
	Fulld	0.66**	1.07	1.70	1.09	0.44†
		(0.49, 0.88)	(0.82, 1.40)	(0.79, 3.65)	(0.97, 1.22)	(0.19, 1.00)
	N	7,889	7,889	863	4,323	1,388

***P < 0.001, **P < 0.01, *P < 0.05, ^†P < 0.1 (two-tailed test).

^aMeasures and cut points used for each marker in Table S1.

^bResults for inflammation are based on data at wave 1 only; results for the other three markers are based on data at waves 1 and 2 and longitudinal residual change models.

^cAdjusted for age, sex, and race.

^dAdjusted for the full set of covariates in Table S3 for each dataset.