Fig. S2.

Schematic diagram for structural modeling of metastable protein oligomers. The procedure for deriving a bias potential using experimental constraints from limited proteolysis is illustrated. The term {cut} is the set of residues at which a proteolytic cut is made. E₁, E₂, E₃, and E₄ are the repulsive potentials applied to (i) the residues that are the site of proteolytic cuts, (ii) residues 1 removed in sequence from cut sites, (iii) residues 2 removed in sequence from cut sites, and (iv) residues 3 removed in sequence from cut sites. E_ij are the interresidue interaction energies applied when residues are within contact range. E_Gō is the interaction energy assigned to native contacts that are in contact range. N_c is the average number of contacts made by each cut site residue.