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. 2015 Dec 30;113(3):614–619. doi: 10.1073/pnas.1516725113

Fig. S3.

Fig. S3.

Folding of SOD1 monomer with various values of λ. (A) λ = 0: SOD1 monomer folding features two distinct states with no folding intermediates. Transitions in energy and the radius of gyration are sharp and well-defined. Trajectories from T = 0.80 and T = 0.85 are located at the transition, and exhibit flipping between folded and unfolded structures. (B) λ = 0.66: SOD1 monomer folding features distinct intermediate states. Transitions in energy and the radius of gyration remain well-defined. Trajectories from T = 0.70, T = 0.75, and T = 0.80 are located at the transition, and exhibit flipping between states. (C) λ = 0.99: SOD1 monomer folding features distinct intermediate states, with a greater separation in energy at λ = 0.66. Transitions in energy and the radius of gyration are well-defined. Trajectories from T = 0.50 and T = 0.55 and from T = 0.75 and T = 0.80 are located at the transitions, and exhibit flipping between two respective states. CV, heat capacity at constant volume.