Table 5.
Interaction of polymorphisms −420C/G and Pro198Leu in NAFLD, n (%)
| Groups | Combined genotype of −420C/G and Pro198Leu | |||
|---|---|---|---|---|
| CC+CG/PP+PL | CC+CG/LL | GG/PP+PL | GG/LL | |
| Control (n = 900) | 584 (64.89) | 103 (11.44) | 98 (10.89) | 115 (12.78) |
| NAFLD (n = 900) | 358 (39.78) | 96 (10.67) | 91 (10.11) | 355 (39.44) |
| OR* | 1.0000 | 1.5204† (OR1) | 1.5148‡ (OR2) | 5.0357§ (OR1×2) |
| 95% CI | 0.9725–2.3982 | 0.9593–2.5481 | 3.1852–7.8106 | |
| β | 0.1820† (β1) | 0.1804‡ (β2) | 0.7021§ (β1×2) | |
| P | 0.0385 | 0.0269 | 0.0054 | |
*Adjusted for sex, age, and smoking status; †OR value by simple Pro198Leu homozygous mutant exposure (OR1 [β1]); ‡OR value by simple −420C/G homozygous mutant exposure (OR2 [β2]); §OR value by two interacting genes in homozygous mutant (OR1×2 [β1×2]). NAFLD: Nonalcoholic fatty liver disease; CI: Confidence interval; OR: Odds ratio.