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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Chem Asian J. 2015 Sep 4;10(10):2084–2094. doi: 10.1002/asia.201500434

Figure 1.

Figure 1

A) Intercalation of Dox into GC modified aptamer TLS11a to form physical conjugate. Reprinted by permission from reference.[19] Copyright 2012 Meng et al. B) G-quadruplex-aptamer as a drug carrier. The design utilizes the G-quadruplex as the drug carrier and the aptamer as the targeting molecule to deliver TMPyP4, which is known to bind and stabilize different types of quadruplexes. The helical strand represents the aptamer. Reprinted by permission from reference.[20] Copyright 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. C) (Top) Synthesis of ApDCs from phosphoramidites A, T, C, G, and the phosphoramidite containing a drug moiety with a photocleavable linker (denoted as phosphoramdite D). (Bottom) Structural features of phosphoramidite D. Reprinted by permission from reference.[16] Copyright 2014 American Chemical Society.

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