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Schematics of aptamer-tethered DNA nanotrains (aptNTrs) for theranostic applications. A) Self-assembly of aptNTrs from short DNA building blocks initiated by a chimeric aptamer-tethered trigger probe. The tethered aptamers work as locomotives with multiple repetitive “boxcars” to be loaded with molecular drugs. B) The drugs are specifically transported to target cancer cells via aptNTrs. Reprinted by permission from reference.[15d] Copyright 2013 Zhu et al.
