Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Neurological sequelae
[8] RCT 5-armed trial	101 children presenting with severe malaria, positive test for Plasmodium falciparum, and moderate acidosis	Neurological sequelae timeframe not stated 1/35 (3%) with saline bolus (bolus over 1 hour) 0/33 (0%) with usual care (no bolus, maintenance fluids only)	Significance of difference between groups not assessed