Table 1. clinical characteristics of HLA-B27 associated AU patients and overall scores on questionnaires (N and (%) or Mean ± SD (range)).
| Patients who filled out the questionnaires | Patients who did not fill out the questionnaires | p | |
|---|---|---|---|
| Number of patients | 59 | 56 | - |
| Female / male | 23 (39%) / 36 (61%) | 22 (39%) /34 (61%) | 0.973 |
| Age at completing questionnaire / study (yrs) | 54 ± 12 (28–81) | 46 ± 15 (19–90) | 0.001 |
| Unilateral / bilateral* | 28 (47%) / 31 (53%) | 21 (38%) / 35 (63%) | 0.280 |
| Total uveitis episodes | 7.3 ± 6.5 (1–40) | 6.8 ± 6.3 (1–24) | 0.579 |
| Time of active uveitis (months) | 5.8 ± 5.0 (1–30) | 5.5 ± 6.0 (1–30) | 0.753 |
| Follow-up time (yrs) | 13.6 ± 9.7 (0.03–36.0) | 9.9 ± 9.6 (0.02–29.8) | 0.039 |
| Remission time (yrs) | 3.2 ± 2.8 (0.00–12.0) | 3.4 ± 3.4 (0.09–15.4) | 0.721 |
| Depression in past† | 4 (7%) | - | - |
| Present depression | 6 (10%) | - | - |
| HLA-B27 tested (% of total group) | 43 (73%) | 44 (79%) | 0.477 |
| HLA-B27 positive (% of tested) | 43 (100%) | 44 (100%) | - |
| HLA-B27 not tested (% of total group)‡ | 16 (27%) | 12 (21%) | 0.477 |
| Systemic disease | 34 (58%) | 27 (48%) | 0.312 |
| - Ankylosing spondylitis | 26 (44%) | 22 (39%) | - |
| - Reactive arthritis | 3 (5%) | 0 (0%) | - |
| - Crohn / Colitis ulcerosa | 2 (3%) | 2 (4%) | - |
| - Other | 3 (5%) | 3 (5%) | - |
| Ocular complications§ | 53 (90%) | 46 (82%) | 0.234 |
| - Posterior synechiae | 37 (63%) | 29 (52%) | - |
| - Elevated IOP | 22 (37%) | 25 (45%) | - |
| - Dry Eyes|| | 17 (29%) | 11 (20%) | - |
| - Cataract | 16 (27%) | 16 (29%) | - |
| - CME | 8 (14%) | 7 (13%) | - |
| - Secondary cataract | 4 (7%) | 2 (4%) | - |
| - Papillitis | 3 (5%) | 3 (5%) | - |
| - Glaucoma | 2 (3%) | 1 (2%) | - |
| NEI VFQ-25 OCS# | 88.9 ± 8.8 (53.7–98.0) | - | - |
| BDI-II score | 4.7 ± 5.3 (0–19) | - | - |
| SSL-I score | 76.2 ± 15.3 (34–104) | - | - |
| SSL-D score | 42.1 ± 11.5 (34–80) | - | - |
AU: anterior uveitis, IOP: Intraocular Pressure, CME: Cystoid Macular Edema, OCS: Overall Composite Score, BDI: Beck Depression Inventory, SSL-I: Social Support List—Interactions, SSL-D: Social Support List—Discrepancies.
* Simultaneously bilateral or alternating between the right and left eye.
† Diagnosed by a physician and medically treated.
‡ All patients that have not been tested for HLA-B27 positivity (n = 17), were diagnosed with an HLA-B27 associated systemic disease by a rheumatologist.
§ Developed during follow-up AU and in at least one eye.
|| Medication needed.
# Average of vision-targeted subscale scores, without general health subscore.