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. 2016 Jan 21;12:219–227. doi: 10.2147/NDT.S90960

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© 2016 Liu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Effect of chronic GEBR-7b treatment on CUS-induced depression-like behaviors in rats.

Notes: (A) Schematic representation of the experimental procedure for CUS and treatments in rats. CUS rats were exposed to one stressor per day for 21 days, and then received 14 days of GEBR-7b or vehicle injections during which CUS continued. (B) OFT: exploratory activities (total distance traveled) were evaluated in a 5-minute test session. (C) OFT: movement velocity was evaluated in a 5-minute test session. (D) FST: time spent for immobility was scored for a 5-minute-test session. Results are expressed as mean ± SEM (n=8 per group). *P<0.01, compared to nonstressed rats treated with vehicle; **P<0.05.

Abbreviations: CUS, chronic unpredictable stress; OFT, open field test; FST, forced swimming test; SEM, standard error of the mean; ip, intraperitoneal injection.