Table 1.

Summary of human ARTs.

Subfamily	Name	Aliases	Size (aa)	Subcellular Localization	Triad Motif	Key Domains	Activity
DNA dependent	ARTD1 ARTD2 ARTD3	PARP1 PARP2 PARP3	1014 583 533	Nucleus Nucleus and cytoplasm Nucleus and cytoplasm	H-Y-E H-Y-E H-Y-E	zinc fingers, BRCT, WGR WGR, DBD WGR	P P M
Tankyrase	ARTD5 ARTD6	PARP5a, TANK1 PARP5b, TANK2	1327 1166	cytoplasm cytoplasm	H-Y-E H-Y-E	Ankyrin repeat Ankyrin repeat	P P
CCCH Zn Finger	ARTD14 ARTD12 ARTD13	PARP7, tiPARP PARP12 PARP13, ZC3HAV1	657 701 902	Nucleus and cytoplasm cytoplasm cytoplasm	H-Y-I H-Y-I Y-Y-V	zinc fingers, WWE zinc fingers, WWE zinc fingers, WWE	M M I
Macro	ARTD9 ARTD8 ARTD7	PARP9, BAL1 PARP14, BAL2 PARP15, BAL3	854 1801 678	Nucleus and cytoplasm Nucleus and cytoplasm ND	Q-Y-T H-Y-L H-Y-L	macro domain macro domain, WWE macro domain	I M M
unclassified	ARTD4 ARTD17 ARTD16 ARTD10 ARTD11 ARTD15	PARP4 PARP6 PARP8 PARP10 PARP11 PARP16	1724 630 854 1025 331 322	Nucleus and cytoplasm cytoplasm cytoplasm Nucleus and cytoplasm Nucleus and cytoplasm cytoplasm	H-Y-E H-Y-Y H-Y-I H-Y-I H-Y-I H-Y-I	BRCT RRM, UIM WWE	M M M M M M
tRNA phosphotransferase	ARTD18	TRPT1, TpT1	253	cytoplasm	H-H-V
ecto-ARTs	ARTC1 ARTC2P ARTC3 ARTC4 ARTC5	ART1 ART2P ART3 ART4 ART5	327 389 314 291	ER, plasma membrane plasma membrane, ER plasma membrane extracellular	R-S-E K-L-V G-S-E R-S-E		M M M M

Note: P, PARylation; M, mono ADP-ribosylation; I, inactive enzyme; ND, not determined.