Table 2.
Substrate specificity of aldonolactone oxidoreductases towards each other's preferred substrates
| Source | l-Gulono-1,4-lactone | d-Mannono-1,4-lactone | l-Galactono-1,4-lactone | d-Altrono-1,4-lactone | d-Arabinono-1,4-lactone | d-Glucono-1,4-lactone | References | |
|---|---|---|---|---|---|---|---|---|
| Animals | Rat | 100 | 68 | 87 | 47 | 22 | NDd | Ashwell et al., 1961 |
| Rat | 100 (0.066 mM) | 61 | 70 | 15 | ND | <3 | Kiuchi et al., 1982 | |
| Nishikimi et al., 1976 | ||||||||
| Chicken | 100 (0.007 mM) | 64 | 90 | 16 | ND | <3 | Kiuchi et al., 1982 | |
| Goat | 100 (0.15 mM) | ND | ND | ND | ND | ND | Nishikimi et al., 1976 | |
| Fungi | S. cerevisiae | 32 | <3 | 100 | 68 | ND | <3 | Nishikimi et al., 1978 |
| S. cerevisiae | 0 | ND | 100 (0.30 mM) | 65 (2.0 mM) | 97 (0.16 mM) | ND | Bleeg and Christensen, 1982 | |
| C. albicans | 24.7 | ND | 87.6 (53.7 mM) | ND | 100 (44.1 mM) | NDd | Huh et al., 1994 | |
| P. griseoroseum | 0 | 0 | ND | ND | ND | 100e (1.7 mM) | Takahashi et al., 1976 | |
| P. notatum | ND | ND | 0 | 0 | ND | 100 | Takahashi, 1969 | |
| G. frondosa | 100 (24 mM) | 25 | 2 | 0 | 0 | NDd | Okamura, 2001 | |
| L. edodes | 100 | 24 | 0 | 0 | 0 | NDd | Okamura, 2001 | |
| Bacteria | M. tuberculosis | 100 (5.5 mM) | ND | 0 | ND | ND | ND | Wolucka and Communi, 2006 |
| G. oxydans | 100 (34.8 mM) | ND | 0 | ND | ND | NDd | Sugisawa et al., 1995 | |
| Protozoa | T. brucei | 3 | ND | 77 (0.154 mM) | ND | 100 (0.055 mM) | ND | Wilkinson et al., 2005 |
| T. cruzi | 0 | ND | 100 (0.161 mM) | ND | 96 (0.285 mM) | ND | Logan et al., 2005 | |
| L. donovani | 0 | ND | ND | ND | 100 (0.039 mM) | ND | Biyani and Madhubala, 2011 | |
| Algae | E. gracilis | 71 | ND | 100 | ND | ND | ND | Shigeoka et al., 1979 |
| Plants | Cauliflower | 0 | 0 | 100 (2 and 4 mM)a | 10 | ND | 0 | Mapson and Breslow, 1958 |
| Cauliflower | 0 | ND | 100 (3.3 mM) | ND | ND | ND | Østergaard et al., 1977 | |
| White potato | 19.5 | ND | 100 (0.08 and 0.23 mM)b | ND | ND | ND | Ôba et al., 1994 | |
| Sweet potato | 1 | ND | 100 (0.12 mM) | ND | ND | ND | Ôba et al., 1995 | |
| Spinach | 0 | ND | 100 (0.192 mM) | ND | ND | ND | Mutsuda et al., 1995 | |
| Tobacco | 7 | ND | 100 (0.06 and 0.08 mM)c | ND | ND | ND | Yabuta et al., 2000 | |
| Strawberry | 0 | ND | 100 | ND | ND | ND | Nascimento et al., 2005 | |
| Arabidopsis | (13.1 mM) | ND | 100 (0.17 mM) | ND | 10.2 mM | ND | Leferink et al., 2008b | |
| Leferink et al., 2009c | ||||||||
a
with different electron acceptors
b
with different methods
c
with native and recombinant enzymes
d
No or very less activity with Dglucono-1,5-lactone
e
similar result with d-glucono-1,5-lactone; ND, not determined. Numbers in the parantheses indicate the substrate affinity values (Km).