. Author manuscript; available in PMC: 2017 Jan 1.

Published in final edited form as: Plant Physiol Biochem. 2015 Nov 27;98:171–185. doi: 10.1016/j.plaphy.2015.11.017

Table 3.

A comparison of the effects of different classes of inhibitors on aldonolactone oxidoreductases

	Source	Sulfhydryl group inhibitors	Metal ions	Metal Chelating agents	Substrate analogs	Flavin inhibitors	Reference
Animals	Rat	Sufide, sulfite, PCMS	1-Hg²⁺ 2-Cd²⁺	Nil	ND	Nil	Nakagawa and Asano, 1970

Fungi	S. cerevisiae	PCMS, iodoacetamide, NEM, sulfite, sulfide	1 -Hg²⁺, Cd²⁺	Nil	l-GulL, d-GalL	ND	Bleeg and Christensen, 1982
	S. cerevisiae	PCMB	ND	Nil	Nil	ND	Nishikimi et al., 1978
	C. albicans	PCMB, NEM, iodoacetic acid, iodoacetamide	1-Cd²⁺, Hg²⁺, Mn²⁺, Zn²⁺ 2-Cu²⁺, Mg²⁺	Nil	d-Glucono-1,5-lactone, l-AL, d-GalL, d-GulL	ND	Huh et al., 1994
	P. griseoroseum	Nil	1-Hg²⁺, Ag²⁺, Fe³⁺, Fe²⁺, Cu²⁺ 2- Co²⁺, Mn²⁺, Zn²⁺, Cd²⁺, Mg²⁺, Ca²⁺, As²⁺	ND	ND	ND	Takahashi et al., 1976
	P. notatum	PCMB	ND	Nil	ND	ND	Takahashi, 1969
	G. frondosa	Nil	ND	ND	ND	Acriflavine	Okamura, 2001

Bacteria	M. tuberculosis	NEM	1-Cu²⁺, Zn²⁺ 2-Mg²⁺, Ca²⁺ 3-Mn²⁺	EDTA, KCN	ND	Nil	Wolucka and Communi, 2006
Bacteria	G. oxydans	Nil	1 -Cu²⁺, Mn²⁺ 3 -Fe⁶⁺, Mo⁶⁺, Ti⁺, Zn²⁺, Ni²⁺	Nil	ND	ND	Sugisawa et al., 1995

Protozoa	T. brucei	ND	3 -Cu²⁺	ND	Substrate >4mM	ND	Wilkinson et al., 2005
	T. cruzi	PCMB, NEM	1 -Hg²⁺, Zn²⁺	ND	ND	ND	Logan et al., 2007
	L. donovani	NEM	1 -Zn²⁺, Hg²⁺	ND	ND	ND	Biyani and Madhubala, 2011

Algae	E. gracilis	PCMB, NEM	1 -Cu²⁺, Zn²⁺, Fe²⁺	Nil	ND	Riboflavin	Shigeoka et al., 1979

Plants	Cauliflower	PCMB, o-Iodosobenzoate	1-Cu²⁺ 2-Mn²⁺, Zn²⁺, Fe³⁺, MoO₄²⁻	o-phenanthroline	d-GulL, d-GalL	Atebrin, Riboflavin	Mapson and Breslow, 1958
	Cauliflower	PHMB, NEM, monoiodoacetate	Nil	Nil	l-GalL – 32.6 mM	Nil	Østergaard et al., 1997
	Sweet potato	PCMB, NEM*	1- Cu²⁺, Zn²⁺*	ND	l-GalL ≥ 4 mM	Acriflavine	Ôba et al.,1995; * Imai et al.,1998
	Spinach	PCMB, NEM	ND	ND	l-GalL > 1 mM	ND	Mutsuda et al., 1995
	Tobacco	PCMB, NEM	Cu²⁺, Zn²⁺	ND	ND	Acriflavine	Yabuta et al., 2000
	Strawberry	ND	ND	ND	l-GalL > 10 mM	ND	Nascimento et al., 2005
	Arabidopsis	DTNB, NEM	ND	ND	l-GalL > 2 mM*	ND	* Leferink et al., 2008b; Leferink, 2009a

1: inhibitory, 2: not inhibitory, 3: slightly inhibitory, Nil: no inhibition found, DTNB: 5,5′ -dithiobis(2-nitrobenzoic acid), NEM: N-ethylmaleimide, PCMB: p-chloromercuribenzoate, PCMS: p-chloromercurisulfate, PHMB: p-hydroxymercuribenzoate. ND: not determined