Table 4. Top 20 most highly down-regulated mRNAs in the oviducts of ESR1KO versus WT mice.

Overall Model: P < 0.01 and at least a 2-fold change in gene expression.

Gene Symbol	Gene Description	P-value	Fold-Change
Pcdh17	protocadherin 17	< 0.001	-10.6901
Csf3	colony stimulating factor 3 (granulocyte)	0.002	-11.5917
Tshr	thyroid stimulating hormone receptor	< 0.001	-11.8455
Col6a4	collagen, type VI, alpha 4	< 0.001	-12.206
Akr1c14	aldo-keto reductase family 1, member C14	< 0.001	-12.2614
Upk1a	uroplakin 1A	0.001	-12.9078
Slc6a2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	< 0.001	-13.1394
Lrat	lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)	< 0.001	-13.3562
Ano4	anoctamin 4	0.002	-13.6892
Gp1bb	glycoprotein Ib, beta polypeptide	< 0.001	-15.0412
Stat5a	signal transducer and activator of transcription 5A	< 0.001	-16.1053
Rtn1	reticulon 1	< 0.001	-18.0311
Syn2	synapsin II	< 0.001	-23.8067
Ramp3	receptor (calcitonin) activity modifying protein 3	< 0.001	-24.6301
Mlc1	megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)	< 0.001	-29.3425
Hpgds	hematopoietic prostaglandin D synthase	0.001	-32.2313
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.001	-39.5376
Dcpp1 /// Dcpp2 /// Dcpp3	demilune cell and parotid protein 1 /// demilune cell and parotid protein 2 /// demilune cell and parotid protein 3	< 0.001	-47.7492
2300002M23Rik	RIKEN cDNA 2300002M23 gene	0.003	-71.6374
Dcpp3	demilune cell and parotid protein 3	< 0.001	-77.6391

Fold-Change in gene expression and P-Values are indicated. Negative changes in fold-change represent decreased expression in the oviducts of ESR1KO mice.