Table 1. Association between FAS rs2234767, rs1800682 and FASLG rs763110 genotypes and risk of CRC.
SNPs | Genotype | Cases (n = 878) |
Controls (n = 884) |
Pa | Pb | Adjusted OR (95% CI)c | ||
---|---|---|---|---|---|---|---|---|
n | % | n | % | |||||
FASLG | CC | 462 | 53 | 470 | 53 | 0.71 | 1.0 | 1.00 (Ref) |
rs763110 | CT | 354 | 40 | 344 | 39 | 1.06 (0.87–1.28) | ||
TT | 62 | 7 | 70 | 8 | 0.90 (0.62–1.30) | |||
Ptrend | 0.92 | |||||||
T allele | 478 | 27 | 484 | 27 | 0.92 | 1.0 | ||
FAS | GG | 305 | 37 | 385 | 44 | 0.0051 | 0.015 | 1.00 (Ref) |
rs2234767 | GA | 407 | 49 | 372 | 43 | 1.39 (1.13–1.71) | ||
AA | 124 | 15 | 114 | 13 | 1.37 (1.02–1.84) | |||
Ptrend | 0.0051 | |||||||
A allele | 655 | 39 | 600 | 34 | 0.0042 | 0.013 | ||
GG | 305 | 36 | 385 | 44 | 1.00 (Ref) | |||
GA/AA | 531 | 64 | 486 | 56 | 1.38 (1.14–1.68) | |||
FAS | AA | 301 | 34 | 348 | 40 | 0.060 | 0.18 | 1.00 (Ref) |
rs1800682 | AG | 435 | 50 | 392 | 44 | 1.30 (1.06–1.60) | ||
GG | 142 | 16 | 144 | 16 | 1.16 (0.88–1.53) | |||
Ptrend | 0.14 | |||||||
G allele | 719 | 41 | 680 | 38 | 0.13 | 0.39 | ||
AA | 301 | 34 | 348 | 39 | 1.00 (Ref) | |||
AG/GG | 577 | 66 | 536 | 61 | 1.26 (1.04–1.53) |
Bold indicated statistically significant.
aχ2 test for either genotype distributions or allele frequencies between the cases and controls.
bAdjusted for multiple comparisons by Bonferroni correction.
cAdjusted for age, sex, smoking and drinking status in logistic regression model.