Table 2. Combined genotype frequencies of the FAS polymorphisms among the cases and controls and their association with risk of CRC.
| Combined genotypes | Cases (n = 836) | Controls (n = 871) | Pa | Adjusted OR (95% CI)b | |
|---|---|---|---|---|---|
| n (%) | n (%) | ||||
| FAS rs2234767 | FAS rs1800682 | <0.001 | |||
| GG | AA | 287 (34) | 347 (40) | 1.00 (Reference) | |
| GG | AG/GG | 18 (2) | 38 (3.9) | 0.60 (0.33–1.07) | |
| GA/AA | AA | 13 (2) | 1 (0.1) | 15.49 (2.01–119.25) | |
| GA/AA | AG/GG | 518 (62) | 485 (56) | 1.30 (1.06–1.59) | |
| Trend test | 0.0051 |
Bold indicated statistically significant.
aχ2 test for the combined genotype distributions between the cases and controls.
bAdjusted for age, sex, smoking and drinking status in logistic regression model.