Table 4. Association between the FAS combined genotypes and progression of CRC.
| Variables | Combined genotypes |
Pa | Adjusted OR (95% CI)b | |||
|---|---|---|---|---|---|---|
| With rs2234767 GG/rs1800682 AA |
Without rs2234767 GG/rs1800682 AA |
|||||
| n | % | n | % | |||
| Controls (n = 871) | 347 | 40 | 524 | 60 | 1.00 (reference) | |
| Cases (n = 836) | ||||||
| Tumor grade | ||||||
| Low | 24 | 40 | 36 | 60 | 0.98 | 0.99 (0.58–1.70) |
| Intermediate | 219 | 34 | 427 | 66 | 0.018 | 1.30 (1.05–1.61) |
| High | 44 | 34 | 86 | 66 | 0.19 | 1.30 (0.88–1.91) |
| Dukes stage | ||||||
| A + B | 150 | 35 | 275 | 65 | 0.11 | 1.22 (0.96–1.55) |
| C + D | 137 | 33 | 274 | 67 | 0.025 | 1.33 (1.04–1.71) |
Bold indicated statistically significant.
aχ2 test for the combined genotype distributions between the cases and controls.
bAdjusted for age, sex, smoking and drinking status in logistic regression model.