Fig 2. Deficiency of LspA partially reverses M. bovis BCG-mediated induction of HIV infectivity of CD4+ T cells.

The percentage of GFP+ CD4+ T cells following no stimulation (Unstim), or stimulation of PBMC with M. bovis BCG Copenhagen (BCG), M. smegmatis MC²155 containing empty vector (M. smeg), or a M. bovis BCG strain lacking lipoprotein signal peptidase A (BCGΔlspA), which fails to produce mature lipoproteins. Results represent combined flow cytometric analysis of CD4+ cells after infection with an X4-tropic GFP+ pseudovirus, from 3 independent experiments. * p< 0.05