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. 2016 Jan 13;6:19026. doi: 10.1038/srep19026

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Copyright © 2016, Macmillan Publishers Limited

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(A) Axial view of basal ganglia slice showing the volumes of interest for multivoxel MRS. (B–D) Examples of attained spectra of the RPCG by LCModel evaluation of metabolite values: (B) HC, (C) non-NPSLE patient and (D) NPSLE patient. We found NAA decreased significantly in NPSLE patients (p < 0.01), followed by non-NPSLE patients (p > 0.05), while tCr levels decreased in NPSLE (p < 0.01) and non-NPSLE patients (p < 0.01) compared with HC. Abbreviations: MRS = magnetic resonance spectroscopy; NPSLE = neuropsychiatric systemic lupus erythematosus; HC = healthy control; RPCG = right posterior cingulate gyrus; NAA = N-acetylaspartate; Cho = choline; tCr = total creatine; MI = myoinositol; Glx = glutamine + glutamate.